Update on leukotriene receptor antagonists in preschool children wheezing disorders

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Update on leukotriene receptor antagonists in preschool children wheezing disorders

Asthma is the most common chronic disease in young children. About 40% of all preschool children regularly wheeze during common cold infections. The heterogeneity of wheezing phenotypes early in life and various anatomical and emotional factors unique to young children present significant challenges in the clinical management of this problem. Anti-inflammatory therapy, mainly consisting of inha...

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Development of wheezing disorders and asthma in preschool children.

Recent longitudinal studies have shed light on the pathogenesis and progression of asthma. The patterns of expression of childhood asthma that persist into adult life have been explored. Distinct asthma phenotypes (transient wheezing, nonatopic wheezing, and atopy-associated asthma) have been identified. Defining which children are at risk for persistent asthma could allow for better management...

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Side effects of the leukotriene receptor antagonists in asthmatic children

Results It was found out that 67.5% of 41 (4%) patients in whom side effects were observed was male and their average age was 6.5. The rate of patients with asthma was 63.41% and it was 36.58% for patients with early wheezing. It was determined that sex, age and diagnosis (early wheezing or asthma) of the patients were ineffective in the emergence of side effects. The average period for the eme...

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Side Effects of Leukotriene Receptor Antagonists in Asthmatic Children

BACKGROUND Leukotriene receptor antagonists (LTRAs) are drugs which have been widely used more than ten years. As the use of LTRAs increases, our knowledge with respect to their side effects increases as well. OBJECTIVES The objective of our study was to evaluat the observed side effects of LTRAs used in patients with astma. PATIENTS AND METHODS 1024 patients treated only with LTRAs owing t...

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A Disease Model for Wheezing Disorders in Preschool Children Based on Clinicians' Perceptions

BACKGROUND Wheezing disorders in childhood vary widely in clinical presentation and disease course. During the last years, several ways to classify wheezing children into different disease phenotypes have been proposed and are increasingly used for clinical guidance, but validation of these hypothetical entities is difficult. METHODOLOGY/PRINCIPAL FINDINGS The aim of this study was to develop...

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ژورنال

عنوان ژورنال: Italian Journal of Pediatrics

سال: 2012

ISSN: 1824-7288

DOI: 10.1186/1824-7288-38-29